First dissolved in DMSO (50 mg/ml); or Water (50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Tribioscience Camostat Mesilate, Serine Protease Inhibitor (TBI2196)
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Tribioscience Camostat Mesilate, Serine Protease Inhibitor (TBI2196)
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Product Details
Formal Name: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate, methanesul-fonic acid salt
Alternate Names: Methanesulfonic acid salt; FOY-305; Foipan
Molecular Formula: C20H22N4O5 • CH3SO3H
Formula Weight: 494.50
CAS Number: 59721-29-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (50 mg/ml); or Water (50 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Serine protease inhibitor
Functions
A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. Reduces weight gain and improves metabolism in obese rodent models. In clinical use (in Japan) for pancreatitis. Inhibits influenza virus replication in human tracheal epithelial cells. Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.
Application Procedures