First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.
Tribioscience BIBW 2992 (Afatinib), EGFR and HER2 Inhibitor (TBI4510)
SKU: TBI4510-10MG
Tribioscience BIBW 2992 (Afatinib), EGFR and HER2 Inhibitor (TBI4510)
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Product Details
Formal Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2E-butenamide
Alternate Names: BIBW2992
Molecular Formula: C24H25ClFN5O3
Formula Weight: 485.94
CAS Number: 439081-18-2
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
EGFR and HER2 inhibitor
Functions
Afatinib is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50 = 0.5 nM) and HER2 (IC50 = 14 nM).
Application Procedures