Product Details
Formal Name: 2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Molecular Formula: C16H14N2O4
Formula Weight: 298.30
CAS Number: 68302-57-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 60 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
TBK1 inhibitor; Antidiabetic
Functions
Improves obesity-related metabolic dysfunction in mouse models. Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1 (TBK1) and IKKε (IC50=1.2 μM). Clinically useful in the treatment of aphthus ulcers. Inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling.
Application Procedures
First dissolved in DMSO (up to 60 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.