TNK2 Polyclonal Antibody Store at -20°C
SKU: E-AB-15457-200
TNK2 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15457 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human TNK2 |
| Abbre | TNK2 |
| Synonyms | ACK, ACK 1, ACK-1, ACK1, Acetate kinase 1, Acetokinase 1, Activated CDC42 kinase 1, Activated Cdc42 associated kinase 1, Activated p21cdc42Hs kinase, FLJ44758, FLJ45547, TNK 2, TNK2, Tyrosine kinase non receptor 2, Tyrosine kinase non receptor protein 2, p21cdc42Hs |
| Swissprot | |
| Cellular Localization | Cell membrane. Nucleus. Endosome. Cell junction>adherens junction. Cytoplasmic vesicle membrane. The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.