SOX-2 Monoclonal Antibody
SKU: PA7179-1.5
SOX-2 Monoclonal Antibody
Product Details
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Synonyms | SOX-2 |
| Cellular Localization | nucleus |
| Tissue Specificity | Tonsil |
| Storage | The RTU should be stored at 2~8°C protecting from light (Do not freeze),Valid for 12 months. |
| Shipping | Ice bag |
Background
The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors, which plays an important role in early organ development. SOX2 can be used in the auxiliary diagnosis of germ cell tumors. 90% of embryonic cancers express SOX2, but not in seminoma, yolk sac tumor and choriocarcinoma. SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers. In small cell lung cancers, SOX2 was also correlated with a poor prognosis. Conversely, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and was shown to be an independent positive prognostic marker.