SMG8 Polyclonal Antibody
SKU: E-AB-12757-200
SMG8 Polyclonal Antibody
| SKU # | E-AB-12757 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human SMG8 |
| Abbre | SMG8 |
| Synonyms | ABC 2, ABC2, Amplified in breast cancer gene 2 protein, Chromosome 17 open reading, FLJ10587, Protein smg 8 homolog, SMG8, SMG8 protein, chromosome 17 open reading frame 71, protein SMG8 |
| Swissprot | |
| Cellular Localization | Cytosol |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:25-1:100 |
Background
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.