RNASE1 Polyclonal Antibody Reactivity Human
SKU: E-AB-53050-200
RNASE1 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-53050 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human RNASE1 |
| Abbre | RNASE1 |
| Synonyms | HP-RNase, Pancreatic ribonuclease, RIB-1, RNAS1_HUMAN, RNAseA, RNase 1, RNase A, RNase UpI-1, Rib 1, Rib1, Ribonuclease 1, Ribonuclease A, Ribonuclease RNase A family 1, Ribonuclease RNase A family 1 pancreatic, Ribonuclease a family 1, Ribonuclease pancreatic, Rnase1 |
| Swissprot | |
| Calculated MW | 18 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Extracellular region or secreted. |
| Concentration | 0.72 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.