Recombinant Mouse MMP12/MMP-12/HME Protein (His Tag)
SKU: PKSM041106-50
Recombinant Mouse MMP12/MMP-12/HME Protein (His Tag)
| SKU # | PKSM041106 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | MME, MMP-12, Macrophage metalloelastase, Matrix metalloproteinase-12, Mme, Mmel, Mmp12 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Ala29-Cys473 |
| Accession | P34960 |
| Calculated Molecular Weight | 53.0 kDa |
| Observed Molecular Weight | 64 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 500mM NaCl,0.01%Tween 80, 1mM EDTA, 50% Glycerol, pH6.0. |
| Reconstitution | Not Applicable |
Background
Matrix metalloproteinase-12（MMP12） is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. It can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.