Recombinant Mouse IL-17B protein(N-His)(active)
SKU: PKSM041494-100
Recombinant Mouse IL-17B protein(N-His)(active)
| SKU # | PKSM041494 |
| Expression Host | E.coli |
Description
| Synonyms | Zcyto, hlb38, hlb382, LTalpha, Ltx, lymph, Lymphotoxin-alpha (LT-α), Tnf, Tnfb, TNF-be, Tnfsf, TNFSF1, TNFSF1B, Tnlg1e, Nirf, Zcyto7, Il17b, Tnfb, Tnfsf |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | His 21-Phe 180 |
| Accession | Q9QXT6 |
| Calculated Molecular Weight | 19.0 kDa |
| Observed Molecular Weight | 17-25 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce IL-8 secretion in HepG2 cells. The ED50 for this effect is <1.5 ng/mL. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. In addition to IL-17B, members of the IL-17 family include IL-17A, IL-17C, IL-17D, IL-17E and IL-17F. The six IL-17 cytokines are highly conserved at C terminus, and contain five spatially conserved cysteine residues that mediate dimerization. Expression of IL-17B protein has been reported in neurons, testis, ovary, stomach, pancreas, small intestine and chondrocytes. IL-17B binds to Interleukine-17 receptor B (IL-17 RB) and induces the production of inflammatory cytokines and the infiltration of inflammatory immune cells.