Recombinant Mouse IL-11 protein(N-His)(active)
SKU: PKSM041478-100
Recombinant Mouse IL-11 protein(N-His)(active)
| SKU # | PKSM041478 |
| Expression Host | E.coli |
Description
| Synonyms | Interleukin, IL-11, Interleukin-11, Zcyto1, Zcyto10, Il11, AGIF, interleukin 11 |
| Species | Mouse |
| Expression Host | E.coli |
| Sequence | Pro 22-Leu 199 |
| Accession | P47873 |
| Calculated Molecular Weight | 20.0 kDa |
| Observed Molecular Weight | 17-25 kDa |
| Tag | N-His |
| Bio-activity | Measure by its ability to induce T11 cells proliferation.The ED50 for this effect is <0.5 ng/mL.The specific activity of recombinant mouse IL-11 is > 2 x 106 IU/mg. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. In addition to having lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many other tissues, including the brain, gut, testis and bone.