Recombinant Cynomolgus FGL1 (C-6His)
SKU: PKSQ050095-50
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Recombinant Cynomolgus FGL1 (C-6His)
| SKU # | PKSQ050095 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 425O18-1, Angiopoietin-like protein 4, Angiopoietin-related protein 4, Angptl4, Farp, Fasting-induced adipose factor, Fiaf, HFARP, Hepatic fibrinogen/angiopoietin-related protein, Ng27, Secreted protein Bk89 |
| Species | Cynomolgus macaques |
| Expression Host | HEK293 Cells |
| Sequence | Leu23-Ile312 |
| Accession | A0A2K5X990 |
| Calculated Molecular Weight | 34.8 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | C-His |
| Bio-activity | Loaded Cynomolgus LAG-3-Fc(Cat#PKSQ050015) on Protein A Biosensor, can bind Cynomolgus FGL1-His(Cat#PKSQ050095) with an affinity constant of 28.6nM as determined in BLI assay. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Trehalose, 300mM NaCl, 50% Glycerol, 0.05% Tween 80, pH 8.5. |
| Reconstitution | Not Applicable |
Background
Hepassocin, also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .