MARK2 Polyclonal Antibody
SKU: E-AB-19753-200
MARK2 Polyclonal Antibody
| SKU # | E-AB-19753 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human MARK2 |
| Abbre | MARK2 |
| Synonyms | ELKL motif kinase, ELKL motif kinase 1, EMK-1, EMK1, MAP/microtubule affinity regulating kinase 2, MAP/microtubule affinity-regulating kinase 2, MARK2, MGC99619, Mark2, PAR 1, PAR1 homolog, Par 1b, Par1b, Ser/Thr protein kinase PAR 1B, Serine/threonine protein kinase E |
| Swissprot | |
| Calculated MW | 88 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cell membrane. Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with YWHAZ which promotes relocation from the lateral to the apical membrane. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:10-1:50 |
Background
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.