ITM2B Polyclonal Antibody Reactivity Human
SKU: E-AB-52586-200
ITM2B Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52586 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human ITM2B |
| Abbre | ITM2B |
| Synonyms | ABRI, ABri/ADan amyloid peptide, BRI, BRI 2, BRI2, BRICD 2B, BRICD2B, BRICHOS domain containing 2B, E25B, E3 16, E3-16, FBD, ITM 2B, ITM2B, Immature BRI2, Integral membrane protein 2B, Protein E25B, RDGCA, Transmembrane protein BRI, imBRI2 |
| Swissprot | |
| Calculated MW | 30 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Golgi apparatus membrane. Cell membrane. |
| Concentration | 0.96 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.