IL15RA Polyclonal Antibody Store at -20°C
SKU: E-AB-15727-200
IL15RA Polyclonal Antibody Store at -20°C
| SKU # | E-AB-15727 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human IL15RA |
| Abbre | IL15RA |
| Synonyms | MGC, IL15RA, CD215, alpha, CD215 antigen, IL-15 receptor subunit alpha, IL-15RA, IL-15R-alpha, interleukin 15 receptor, interleukin-15 receptor subunit alpha, MGC104179, AA690181, I15RA, IL 15R alpha, Interleukin 15 receptor alpha, Interleukin 15 receptor subunit alpha, sIL-15 receptor subunit alpha, sIL-15RA, sIL-15R-alpha, Soluble interleukin 15 receptor subunit alpha, Soluble interleukin-15 receptor subunit alpha |
| Swissprot | |
| Cellular Localization | Secreted>extracellular space, Membrane, Nucleus membrane, Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane, Membrane, Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.