IL12RB2 Polyclonal Antibody Store at -20°C
SKU: E-AB-13323-200
IL12RB2 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-13323 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human IL12RB2 |
| Abbre | IL12RB2 |
| Synonyms | RP11 102M, IL12R beta, IL-12R-beta, IL12 receptor beta, IL-12R subunit beta, IL-12 receptor subunit beta, Interleukin 12 receptor beta, Interleukin-12 receptor subunit beta, I12R, Il12rb, IL-12RB, I12R2, IL12 receptor beta 2, IL-12 receptor subunit beta-2, IL12R beta2, IL-12R subunit beta-2, IL-12RB2, IL-12R-beta-2, Interleukin 12 receptor beta 2, Interleukin 12 receptor beta 2 chain, Interleukin-12 receptor subunit beta-2, RP11 102M16.1, IL12RB2 |
| Swissprot | |
| Cellular Localization | Membrane. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Immunology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.