GPNMB Polyclonal Antibody Host Rabbit
SKU: E-AB-40473-200
GPNMB Polyclonal Antibody Host Rabbit
| SKU # | E-AB-40473 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human Transmembrane glycoprotein NMB protein |
| Abbre | GPNMB |
| Synonyms | , Glycoprotein nmb like protein, Gpnmb, HGFIN, NMB, Osteoactivin, Transmembrane glycoprotein, Transmembrane glycoprotein HGFIN, Transmembrane glycoprotein NMB, Glycoprotein nmb |
| Swissprot | |
| Cellular Localization | Cell membrane, Endosome. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Immunology, Cancer |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-1:300 |
Background
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.