GCK Polyclonal Antibody Host Rabbit
SKU: E-AB-40270-200
GCK Polyclonal Antibody Host Rabbit
| SKU # | E-AB-40270 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC, IF |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant Mouse Glucokinase protein |
| Abbre | GCK |
| Synonyms | ATP:D-hexose 6-phosphotransferase, FGQTL3, GCK, GK, GLK, Glucokinase, HHF3, HK IV, HK4, HKIV, HXK4, HXKP, Hexokinase D pancreatic isozyme, Hexokinase type IV, Hexokinase-4, Hexokinase-D, LGLK, MODY2 |
| Swissprot | |
| Calculated MW | 52 kDa |
| Observed MW | 52 kDa
|
| Cellular Localization | Nucleus. Cytoplasm. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:1000-1:2000 |
| IHC | 1:100-1:200 |
| IF | 1:100-1:400 |
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).