FGFRL1 Polyclonal Antibody
SKU: E-AB-11234-200
FGFRL1 Polyclonal Antibody
| SKU # | E-AB-11234 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human FGFRL1 |
| Abbre | FGFRL1 |
| Synonyms | FGF homologous factor receptor, FGF receptor like protein 1, FGF receptor-like protein 1, FGFR 5, FGFR like protein, FGFR-5, FGFR-like protein, FGFR5, FGRL1, FHFR, Fgfrl1, Fibroblast growth, Fibroblast growth factor receptor 5, Fibroblast growth factor receptor like 1 |
| Swissprot | |
| Calculated MW | 55 kDa |
| Cellular Localization | Membrane. Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
| IHC | 1:100-1:300 |
Background
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.