DCTN3 Polyclonal Antibody Store at -20°C
SKU: E-AB-11144-200
DCTN3 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11144 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human DCTN3 |
| Abbre | DCTN3 |
| Synonyms | DCNT22, DCTN 22, DCTN22, DCTN3, Dctn3, Dynactin complex subunit 22 kDa subunit, Dynactin subunit 3, dynactin 3, dynactin 3 (p22), dynactin 3 isoform 1, dynactin light chain, p22 |
| Swissprot | |
| Cellular Localization | Cytoplasm. Cytoplasm>cytoskeleton>centrosome. Chromosome>centromere>kinetochore. Cytoplasm>cytoskeleton>spindle. Cleavage furrow. Midbody. Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-1:300 |
Background
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD.Dynactin binds to both microtubules and cytoplasmic dynein.It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis.This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex.It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin.Alternative splicing results in multiple transcript variants.