CRK Polyclonal Antibody Store at -20°C
SKU: E-AB-11105-200
CRK Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11105 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human CRK |
| Abbre | CRK |
| Synonyms | Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK, CRK isoform 2, CRK isoform II, CRKII, FLJ38130, OTTHUMP00000115366, OTTHUMP00000198330, Proto oncogene C crk, Proto-oncogene C-crk, p38, v crk avian sarcoma virus CT10 oncogene homolog |
| Swissprot | |
| Cellular Localization | Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.