CREBBP Polyclonal Antibody Reactivity Rat
SKU: E-AB-52070-200
CREBBP Polyclonal Antibody Reactivity Rat
| SKU # | E-AB-52070 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CREBBP |
| Abbre | CREBBP |
| Synonyms | CBP, CREB binding protein, CREB-binding protein, Crebbp, Cyclic AMP responsive enhancer binding protein, KAT3A, RSTS, RTS, Rubinstein Taybi syndrome |
| Swissprot | |
| Cellular Localization | Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus. |
| Concentration | 0.96 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:30-1:150 |
Background
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors.First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition.The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex.This protein acetylates both histone and non-histone proteins.This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain.Mutations in this gene cause Rubinstein-Taybi syndrome (RTS).Chromosomal translocations involving this gene have been associated with acute myeloid leukemia.Alternative splicing results in multiple transcript variants encoding different isoforms.