COL1A2 Polyclonal Antibody
SKU: E-AB-10155-200
COL1A2 Polyclonal Antibody
| SKU # | E-AB-10155 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human COL1A2 |
| Abbre | COL1A2 |
| Synonyms | Alpha 2 collagen type I, Alpha 2 type I collagen, Alpha 2 type I procollagen, Alpha 2(I) collagen, Alpha 2(I) procollagen, Alpha-2 type I collagen, CO1A2, COL1A2, Collagen I alpha 2 polypeptide, Collagen alpha 2(I) chain, Collagen alpha-2(I) chain, Collagen of skin |
| Swissprot | |
| Cellular Localization | Secreted>extracellular space>extracellular matrix. |
| Concentration | 0.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:100-1:300 |
Background
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain.Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon.Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.