BABAM2 Polyclonal Antibody Store at -20°C
SKU: E-AB-11008-200
BABAM2 Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11008 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human BRE |
| Abbre | BABAM2 |
| Synonyms | 6030405P19Rik, AI429776, B830038C02Rik, BRCA1 A complex subunit BRE, BRCA1-A complex subunit BRE, BRCA1/BR, Brain and reproductive organ expressed (TNFRSF1A modulator), Brain and reproductive organ-expressed protein, brain and reproductive organ expressed protein |
| Swissprot | |
| Calculated MW | 44 kDa |
| Cellular Localization | Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks. |
| Concentration | 0.5 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:200 |
Background
Brain and reproductive organ-expressed protein (BRE) is a 415 amino acid protein which binds to the intracellular juxtamembrane domain of the death receptor, tumor necrosis factor receptor 1 (TNF-R1). BRE also binds to the death receptor, FAS. BRE downregulates TNFa-induced activation of NFkB and may play a role in homeostasis or cellular differentiation in cells of epithelial, neural and germ line origins. It inhibits components of the death-inducing signaling complexes that are necessary for activation of the mitochondria, thereby mediating apoptosis. BRE is strongly expressed in the adrenal cortex, medulla, testis and pancreas, and is weakly expressed in the thymus, thyroid, stomach and small intestine.