Amphiphysin II Polyclonal Antibody Store at -20°C
SKU: E-AB-13951-200
Amphiphysin II Polyclonal Antibody Store at -20°C
| SKU # | E-AB-13951 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human BIN1 |
| Abbre | Amphiphysin II |
| Synonyms | AMPH 2, AMPH2, AMPHL, Amphiphysin 2, Amphiphysin II, Amphiphysin like protein, Amphiphysin-like protein, BIN1, Bin1, Box Dependant MYC Interacting Protein 1, Box-dependent myc-interacting protein 1, Bridging integrator 1, DKFZp547F068, MGC10367, MGC105, amphiphysin-like |
| Swissprot | |
| Cellular Localization | Cytoplasm and Nucleus. |
| Concentration | 0.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Microbiology |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor.Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin.Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.Studies in mouse suggest that this gene plays an important role in cardiac muscle development.Alternate splicing of the gene results in ten transcript variants encoding different isoforms.Aberrant splice variants expressed in tumor cell lines have also been described.