ABI2 Polyclonal Antibody Reactivity Human
SKU: E-AB-52174-200
ABI2 Polyclonal Antibody Reactivity Human
| SKU # | E-AB-52174 |
| Reactivity |
Human, Mouse |
| Host | Rabbit |
| Applications | WB |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human ABI2 |
| Abbre | ABI2 |
| Synonyms | ABI 2, ABI2, ABI2B, AIP 1, Abelson interactor 2, Abi-2, Abl binding protein 3, Abl interacting protein 1 (SH3 containing protein), Abl interactor 2, Abl interactor protein 2b, Abl-binding protein 3, AblBP3, Arg binding protein 1, Arg protein tyrosine kinase bindi |
| Swissprot | |
| Calculated MW | 56 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasm and Cell projection>lamellipodium. Cell projection>filopodium. Cytoplasm>cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips. |
| Concentration | 0.96 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
Background
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.