Tribioscience CR8 3HCl (R), CDK inhibitor (TBI5507)
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Tribioscience CR8 3HCl (R), CDK inhibitor (TBI5507)
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Product Details
Formal Name: (R)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol
Molecular Formula: C24H29N7O • 3HCl
Formula Weight: 540.90
CAS Number: 294646-77-8
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (30 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
CDK inhibitor
Functions
Second generation analog of roscovitine which inhibits cyclin-dependent kinases with increased potency, Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5, p25, and Cdk9/cyclin T, IC50s=0.09, 0.072, 0.041, 0.11 and 0.18 µM respectively. Acts as a molecular glue degrader that depletes cyclin K. CR8 displays neuroprotective effects in various models including traumatic brain injury.
Application Procedures
First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.