First dissolved in DMSO, methanol, and ethanol, then diluted to aqueous buffer. Solutions in DMSO, methanol, and ethanol may be stored at -20°C for up to 2 months.
Tribioscience Microcystin LR, Protein Phosphatase PP1 and PP2A Inhibitor (TBI2719)
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Tribioscience Microcystin LR, Protein Phosphatase PP1 and PP2A Inhibitor (TBI2719)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: Isolated from Microcystis aeruginosa (a freshwater cyanobacteria)
Molecular Formula: C49H74N10O12
Formula Weight: 995.17
CAS Number: 101043-37-2
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO, methanol, and ethanol
Storage: -20°C
Stability: ≥ 1 year.
Applications
Protein phosphatase PP1 and PP2A inhibitor
Functions
A novel freshwater cyanotoxin. Tumor promoter. Potent and selective inhibitor of protein phosphatase 2A (PP2A), IC50=0.04 nM. PP1, IC50=1.7 nM and PP2B are less sensitive and PP2C is not inhibited (up to 4 μM). Considered to be cell-impermeable with the exception of hepatocytes which take it up via an organic anion transporter.
Application Procedures