Product Details
Formal Name: (R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Alternate Names: CC-5013
Molecular Formula: C13H13N3O3
Formula Weight: 259.26
CAS Number: 191732-72-6
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 30 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
TNFa inhibitor
Functions
Thalidomide analog which, like thalidomide, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death. Cell permeable. Caution: Teratogenic
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.