First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience IPA-3, Selective Inhibitor of PAK1 (TBI4765)
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Tribioscience IPA-3, Selective Inhibitor of PAK1 (TBI4765)
Research Use Only. Not intended for human use.
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Product Details
Formal Name: 1,1′-Dithiodi-2-naphthol
Molecular Formula: C20H14O2S2
Formula Weight: 350.45
CAS Number: 42521-82-4
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Selective inhibitor of PAK1
Functions
IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM) via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc42. IPA-3 has been shown to induce cell death in human leukemic cell lines, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition and inhibits the growth of liver cancer cells.
Application Procedures