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Tribioscience Camostat Mesilate, Serine Protease Inhibitor (TBI2196)

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SKU: TBI2196-10MG
Regular price $ 69.95

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Tribioscience Camostat Mesilate, Serine Protease Inhibitor (TBI2196)

Research Use Only. Not intended for human use.

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Product Details

Formal Name: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate, methanesul-fonic acid salt

Alternate Names: Methanesulfonic acid salt; FOY-305; Foipan

Molecular Formula: C20H22N4O5 • CH3SO3H

Formula Weight: 494.50

CAS Number: 59721-29-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (50 mg/ml); or Water (50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Serine protease inhibitor

Functions

A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis.  Reduces weight gain and improves metabolism in obese rodent models. In clinical use (in Japan) for pancreatitis. Inhibits influenza virus replication in human tracheal epithelial cells. Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.

Application Procedures

First dissolved in DMSO (50 mg/ml); or Water (50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

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