Tribioscience Calphostin C, Protein Kinase C Inhibitor (TBI5635)
Couldn't load pickup availability
Still have questions? Ask our experts!
Tribioscience Calphostin C, Protein Kinase C Inhibitor (TBI5635)
Research Use Only. Not intended for human use.
Buy Tribioscience products from MSE Supplies at the best value.
Product Details
Formal Name: Fermentation product from Cladisporium cladosporioides
Alternate Names: UCN-1028C; PKF115-584
Molecular Formula: C44H38O14
Formula Weight: 790.80
CAS Number: 121263-19-2
Purity: >95%
Formulation: powder
Solubility: Soluble in DMSO (10 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Protein Kinase C inhibitor
Functions
A potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM). Inhibition of PKC is light dependent and is competitive with the diacylglycerol / phorbol ester binding site. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1. Reverses oxycodone-induced tolerance to respiratory depression.
Application Procedures
First dissolved in DMSO (10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.