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Tribioscience Actinomycin D, Transcription Inhibitor

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SKU: TBI2054-5MG
Regular price $ 97.95

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Tribioscience Actinomycin D, Transcription Inhibitor

Research Use Only. Not intended for human use.

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Product Details

Molecular Formula: C62H86N12O16

Formula Weight: 1255.42

CAS Number: 50-76-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Transcription inhibitor

Functions

Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase. Induces apoptosis in a variety of cancer cell lines via the intrinsic pathway.  Upregulates proapoptotic PUMA and downregulates Bcl-2 mRNA in peripheral blood lymphocytes.

Application Procedures

First dissolved in DMSO (up to 2 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.

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