Tribioscience Umifenovir, Antiviral Agent (TBI4472)

Tribioscience Umifenovir, Antiviral Agent (TBI4472)

Research Use Only. Not intended for human use.

Buy Tribioscience products from MSE Supplies at the best value. 

Product Details

Formal Name: 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid, ethyl ester, monohydrochloride

Alternate Names: Arbidol

Molecular Formula: C₂₂H₂₅BrN₂O₃S • HCl

Formula Weight: 513.90

CAS Number: 131707-23-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 15 mg/ml) or in Ethanol (up to at least 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Antiviral agent

Functions

Umifenovir (131707-23-8) is a broad-spectrum antiviral medication. It has shown activity against influenza A,B,and C, respiratory syncytial, SARS-CoV, adeno, parainfluenza type 5, polio, rhino, coxsackie, hanta, chikungungya, hepatitis B and C viruses. It blocks hemagglutinin-mediated membrane fusion of influenza virus particles. Umifenovir has recently been shown to inhibit SARS-CoV2 infection by blocking virus entry as well as release from endolysosomes during intracellular trafficking. It has been suggested that Umifenovir may block trimerization of the spike glycoprotein, a key step in host cell adhesion.

Application Procedures

First dissolved in DMSO (up to at least 15 mg/ml) or in Ethanol (up to at least 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.