Product Details
Formal Name: 7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidibenzo[c,f][1,2]thiazepin-11-yl)amino]heptamoic acid, sodium salt
Molecular Formula: C21H24ClN2O4S Na
Formula Weight: 458.93
CAS Number: 30123-17-2
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
Neuroprotective agent
Functions
Selective enhancer of serotonin uptake in the brain with no effect on noradrenalin or dopamine uptake. Clinically useful antidepressant. Displays neuroprotective effects against hypoxia in cell culture and against the deleterious effects of cytokines in vivo. Induces mTORC1 activation in rat hippocampal neurons and increases dendritic outgrowth, spine density and synaptic proteins. Attenuates LPS-evoked inflammatory activation of microglial cells in culture.
Application Procedures
First dissolved in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.