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Description: TIGIT is an inhibitory receptor expressed on NK cells and T cells. It binds to ligands such as the poliovirus receptor (PVR) and nectin (CD112), which are expressed by antigen-presenting cells and stressed cells, including malignant and virus-infected cells. TIGIT blockade therapies have been shown to enhance NK cell-mediated anti-tumor responses and support CD8+ T cell activity.
Applications:
- in vivo TIGIT stimulation
- Flow cytometry
Molecular Weight: 150 kDa
Host: Mouse
Isotype: Mouse IgG1, Kappa
Concentration: 4 mg/ml
Purity: >95%
Formulation: PBS, pH 7.0, no stabilizers or preservatives.
Endotoxin: < 2EU/mg
Clonality: Monoclonal
Sterility: 0.2 µm filtered
Storage: Store at 4°C for one month. Store at -20°C for long-term storage.