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Description: Cytotoxic T lymphocyte antigen-4 (CTLA-4), also known as CD152, is a regulatory molecule expressed on activated T cells and a subset of regulatory T cells (Tregs). CTLA-4 plays a crucial role in maintaining immune self-tolerance and homeostasis by down-regulating T-cell responses. It has been implicated in the immune dysregulation of several malignancies, including breast cancer, lung cancer, and melanoma, and is a target for cancer immunotherapy.
Applications:
- In vivo CTLA-4 neutralization
- Western blot
Molecular Weight: 150 kDa
Host: Mouse
Isotype: Mouse IgG2b
Concentration: 4 mg/ml
Purity: >95%
Formulation: PBS, pH 7.0, no stabilizers or preservatives.
Endotoxin: < 2EU/mg
Clonality: Monoclonal
Sterility: 0.2 µm filtered
Storage: Store at 4°C for one month. Store at -20°C for long-term storage.