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Tribioscience Sunitinib Malate, VEGFR, PDGFR Kinase Inhibitor (TBI1078)

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SKU: TBI1078-10MG
Regular price $ 104.95

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Tribioscience Sunitinib Malate, VEGFR, PDGFR Kinase Inhibitor (TBI1078)

Research Use Only. Not intended for human use.

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Product Details

Formal Name: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimehyl-1H-pyrrole-3-carboxamide malate

Alternate Names: SU-11248

Molecular Formula: C22H27FN4O4 ∙ C4H6O5

Formula Weight: 532.57

CAS Number: 341031-54-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 13 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

VEGFR, PDGFR kinase inhibitor

Functions

A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRβ and Kit (Ki = 2-17 nM). Also inhibits cFMS (IC50=7 nM) and FLT3. Potent inhibitor of angiogenesis. Clinically useful anticancer agent. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 13 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

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