First dissolved in DMSO (up to 13 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
Tribioscience Sunitinib Malate, VEGFR, PDGFR Kinase Inhibitor (TBI1078)
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Tribioscience Sunitinib Malate, VEGFR, PDGFR Kinase Inhibitor (TBI1078)
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Product Details
Formal Name: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimehyl-1H-pyrrole-3-carboxamide malate
Alternate Names: SU-11248
Molecular Formula: C22H27FN4O4 ∙ C4H6O5
Formula Weight: 532.57
CAS Number: 341031-54-7
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 13 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
VEGFR, PDGFR kinase inhibitor
Functions
A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRβ and Kit (Ki = 2-17 nM). Also inhibits cFMS (IC50=7 nM) and FLT3. Potent inhibitor of angiogenesis. Clinically useful anticancer agent. Cell permeable.
Application Procedures