First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.
Tribioscience Sirtinol, SIRT Inhibitor
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Tribioscience Sirtinol, SIRT Inhibitor
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Product Details
Formal Name: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide
Molecular Formula: C26H22N2O2
Formula Weight: 394.50
CAS Number: 410536-97-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Storage: -20°C / protect from light
Stability: ≥ 1 year.
Applications
SIRT inhibitor
Functions
Selective sirtuin inhibitor which does not effect HDAC1, IC50 = 131, 38 and 68 μM for SIRT1, SIRT2 and Sir2P respectively. Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells. Displays pro-inflammatory effects in adipocytes. Cell permeable.
Application Procedures