Product Details
Formal Name: 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol
Molecular Formula: C21H26ClN3OS
Formula Weight: 403.98
CAS Number: 58-39-9
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Antipsychotic agent
Functions
Perphenazine is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and α-adrenergic. Perphenazine is an inhibitor of acid sphingomyelinase(ASM) and positively effected xenografted tumor growth via perturbation of intracellular cholesterol transport through ASM. It has also been shown to be an inhibitor of glutamate dehydrogenase.
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.