Tribioscience iJMJD6, Arginine Demethylase JMJD6 Inhibitor (TBI4039)

Tribioscience iJMJD6, Arginine Demethylase JMJD6 Inhibitor (TBI4039)

Research Use Only. Not intended for human use.

Buy Tribioscience products from MSE Supplies at the best value. 

Product Details

Formal Name: 3-(3H-Imidazo[4,5-c]pyridine-2-yl)-6-methylchromen-2-one

Alternate Names: WL12

Molecular Formula: C₁₆H₁₁N₃O₂

Formula Weight: 277.30

CAS Number: 899548-78-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 12 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Arginine demethylase JMJD6 inhibitor

Functions

Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins. Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells. Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells.  iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.

Application Procedures

First dissolved in DMSO (up to 12 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.