Product Details
Formal Name: N-hydroxyurea
Alternate Names: Hydroxycarbamide
Molecular Formula: CH4N2O2
Formula Weight: 76.10
CAS Number: 127-07-1
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 50 mg/ml)
Storage: -20°C
Stability: ≥ 2 years.
Applications
Anticancer agent
Functions
Readily oxidized in vivo to free radical forms, which destroy the stable tyrosyl free radical of the metalloenzyme ribonucleotide reductase, suppressing deoxyribonucleotide production and blocking DNA synthesis and repair. Reduces cell proliferation, and causes S-phase arrest and death. Induces p53-dependent NF-κB target gene expression in U2OS cells expressing HA-RelA. Stimulates fetal hemoglobin production in vitro and in vivo. Allows for S phase enrichment of CHO cells with maintenance of viability for enhanced site-specific genome engineering. Anticancer and antiviral agent.
Application Procedures
First dissolved in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 3 months.