Product Details
Formal Name: 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride
Molecular Formula: C13H12N2O·HCl
Formula Weight: 248.71
CAS Number: 343-27-1
Purity: >98%
Formulation: powder
Solubility: Soluble in Water (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
MAO-A and DYRK inhibitor
Functions
Selective competitive and reversible inhibitor of MAO-A (IC50 = 8 µM). Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties. Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.
Application Procedures
First dissolved in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20° for up to 3 months.