First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 2 months.
Tribioscience BIBW 2992 (Afatinib), EGFR and HER2 Inhibitor (TBI4510)
Regular price
$ 96.95
Couldn't load pickup availability
Still have questions? Ask our experts!
Tribioscience BIBW 2992 (Afatinib), EGFR and HER2 Inhibitor (TBI4510)
Research Use Only. Not intended for human use.
Buy Tribioscience products from MSE Supplies at the best value.
Product Details
Formal Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2E-butenamide
Alternate Names: BIBW2992
Molecular Formula: C24H25ClFN5O3
Formula Weight: 485.94
CAS Number: 439081-18-2
Purity: >97%
Formulation: powder
Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
EGFR and HER2 inhibitor
Functions
Afatinib is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50 = 0.5 nM) and HER2 (IC50 = 14 nM).
Application Procedures