First dissolved in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
Tribioscience Bexarotene, Retinoid RXR Agonist (TBI2121)
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Tribioscience Bexarotene, Retinoid RXR Agonist (TBI2121)
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Product Details
Formal Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Alternate Names: LGD-1069; SR-11247
Molecular Formula: C24H28O2
Formula Weight: 348.49
CAS Number: 153559-49-0
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 60 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Storage: -20°C
Stability: ≥ 1 year.
Applications
Retinoid RXR agonist
Functions
A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively). Clinically useful antineoplastic agent for cutaneous T-cell lymphoma Causes complete regression of mammary carcinoma. Bexarotene significantly increases clearance of soluble β-amyloid in a mouse Alzheimer′s model and increases cognitive ability. Reverses apoE4-driven brain pathology and behavioral deficits in vivo.
Application Procedures