CENPC Polyclonal Antibody Store at -20°C
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CENPC Polyclonal Antibody Store at -20°C
| SKU # | E-AB-11073 |
| Reactivity | Human |
| Host | Rabbit |
| Applications | IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human CENPC |
| Abbre | CENPC |
| Synonyms | CENP-C, CENP-C 1, CENPC, CENPC1, Centromere autoantigen C, Centromere autoantigen C1, Centromere protein C, Centromere protein C 1, ICEN7, Interphase centromere complex protein 7, MIF2, hcp-4 |
| Swissprot | |
| Cellular Localization | Nucleus. Chromosome>centromere>kinetochore. Localizes exclusively in the kinetochore domain of centromeres. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| IHC | 1:50-1:200 |
Background
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.