PADI4 Polyclonal Antibody Reactivity Human
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PADI4 Polyclonal Antibody Reactivity Human
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| SKU # | E-AB-52164 |
| Reactivity |
Human |
| Host | Rabbit |
| Applications | WB, IHC |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human PADI4 |
| Abbre | PADI4 |
| Synonyms | EC 3.5.3.15,  HL 60 PAD,  HL-60 PAD,  PAD,  PAD 4,  PADI 4,  PADI 5,  PADI H protein,  PADI4,  PADI5,  PDI 4,  PDI 5,  PDI4,  PDI5,  Padi4,  Peptidyl arginine deiminase type IV,  Peptidyl arginine deiminase type V,  Peptidylarginine deiminase IV,  Protein arginine,  Protein arginine deiminase |
| Swissprot | |
| Calculated MW | 74 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic granule. Cytoplasmic granules of eosinophils and neutrophils. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer,  Epigenetics and Nuclear Signaling,  Metabolism,  Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:40-1:200 |
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Background
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. PADI4 plays a role in the epigenetics, the deimination of arginines on histones 3 and 4 can act antagonistically to arginine methylation. The protein may be found in oligomers and binds 5 calcium ions per subunit. It catalyses the reaction: Protein L-arginine + H2O = protein L-citrulline + NH3.