GBA Polyclonal Antibody
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GBA Polyclonal Antibody
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| SKU # | E-AB-19899 |
| Reactivity | Human,  Mouse |
| Host | Rabbit |
| Applications | WB,  IHC |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human,  Mouse |
| Applications | WB,  IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GBA |
| Abbre | GBA |
| Synonyms | ACID,  Acid beta glucosidase,  Acid beta-glucosidase,  Alglucerase,  BETA GLUCOSIDASE,  Beta glucocerebrosidase,  Beta-glucocerebrosidase,  D glucosyl N acylsphingosine glucohydrolase,  D-glucosyl-N-acylsphingosine glucohydrolase,  EC 3.2.1.45 ,  GBA,  Gba protein ,  betaGC |
| Swissprot | |
| Calculated MW | 60 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Lysosome membrane. Interaction with saposin-C promotes membrane association. |
| Concentration | 1.56 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer,  Metabolism,  Neuroscience,  Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
| IHC | 1:50-1:100 |
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Background Â
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.