ACOD1 Polyclonal Antibody
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ACOD1 Polyclonal Antibody
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| SKU # | E-AB-19833 |
| Reactivity | Human,  Mouse |
| Host | Rabbit |
| Applications | WB |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human,  Mouse |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human ACOD1 |
| Abbre | ACOD1 |
| Synonyms | ACOD1,  Aconitate decarboxylase,  Aconitate decarboxylase 1,  CAD,  Cis aconitate decarboxylase,  IRG1,  Immune responsive gene 1 protein homolog,  Immune-responsive gene 1 protein homolog,  Immunoresponsive 1 homolog (mouse),  Irg1,  OC116,  OPTB1,  TCTIRC7 |
| Swissprot | |
| Calculated MW | 53 kDa |
| Observed MW | Refer to figures |
| Concentration | 1.32 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Metabolism,  Immunology,  Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WB | 1:500-1:2000 |
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Background Â
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.