AAK1 Polyclonal Antibody
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AAK1 Polyclonal Antibody
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| SKU # | E-AB-52133 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB |
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Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human AAK1 |
| Abbre | AAK1 |
| Synonyms | AAK 1,  AAK1,  AP2 associated kinase 1,  AP2 associated protein kinase 1,  AP2-associated protein kinase 1,  Aak1,  Adaptor associated kinase 1,  Adaptor-associated kinase 1,  DKFZp686F03202,  DKFZp686K16132,  FLJ23712,  FLJ25931,  FLJ31060,  FLJ42882,  FLJ45252,  KIAA1048,  M,  MGC138170 |
| Swissprot | |
| Calculated MW | 104 kDa |
| Observed MW | Refer to figures |
| Cellular Localization | Membrane. Cell membrane. Membrane>clathrin-coated pit. Active when found in clathrin-coated pits at the plasma membrane. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
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Related Reagents
| Applications | Recommended Dilution |
| WBÂ | 1:500-1:2000 |
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Background
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.