Recombinant Human EBP1/PA2G4 Protein (His Tag)
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Recombinant Human EBP1/PA2G4 Protein (His Tag)
Recombinant Human EBP1/PA2G4 Protein (His Tag) covers Ser 2-Asp 394 of the human sequence, expressed in E.coli with an N-His tag. Accession is Q9UQ80. Calculated molecular weight is 45.2 kDa and observed molecular weight is 32 kDa. Purity is above 92 % by reducing SDS-PAGE. It is supplied as lyophilized powder, lyophilized from sterile 20mM Tris, 0.5M NaCl, pH 8.0. SKU PKSH030761.
| SKU # | PKSH030761 |
| Expression Host | E.coli |
Description
| Synonyms | EBP1, HG4-1, p38-2G4 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser 2-Asp 394 |
| Accession | Q9UQ80 |
| Calculated Molecular Weight | 45.2 kDa |
| Observed Molecular Weight | 32 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 92 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 20mM Tris, 0.5M NaCl, pH 8.0 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
EBP1, also known as PA2G4, is an RNA-binding protein which belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. PA2G4 can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. EBP1 has been implicated in growth inhibition and the induction of differentiation of human cancer cells. It seems to be involved in growth regulation. EBP1 also mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).